منابع مشابه
Rickettsia Sca4 Reduces Vinculin-Mediated Intercellular Tension to Promote Spread
Spotted fever group (SFG) rickettsiae are human pathogens that infect cells in the vasculature. They disseminate through host tissues by a process of cell-to-cell spread that involves protrusion formation, engulfment, and vacuolar escape. Other bacterial pathogens rely on actin-based motility to provide a physical force for spread. Here, we show that SFG species Rickettsia parkeri typically lac...
متن کاملThe murine gammaherpesvirus 68 ORF27 gene product contributes to intercellular viral spread.
Herpesviruses remain predominantly cell associated within their hosts, implying that they spread between cells by a mechanism distinct from free virion release. We previously identified the efficient release of murine gammaherpesvirus 68 (MHV-68) virions as a function of the viral gp150 protein. Here we show that the MHV-68 ORF27 gene product, gp48, contributes to the direct spread of viruses f...
متن کاملInfluenza A virus uses intercellular connections to spread to 3 neighboring cells 4 5
Running title: Influenza virus spreads intercellularly 10 11 Abstract word count = 248 words 12 Main text word count = 7788 words 13 14 15 16 17 To whom correspondence should be addressed: Dept. of Molecular Biosciences, 18 Northwestern University, 2205 Tech Drive, Evanston, IL 60208-3500 19 Telephone: 847-491-5433; Fax: 847-491-2467; e-mail: [email protected] 20 21 JVI Accepts, published...
متن کاملPenton-Dodecahedral Particles Trigger Opening of Intercellular Junctions and Facilitate Viral Spread during Adenovirus Serotype 3 Infection of Epithelial Cells
Human adenovirus serotypes Ad3, Ad7, Ad11, and Ad14 use the epithelial junction protein desmoglein 2 (DSG2) as a receptor for infection. During Ad infection, the fiber and penton base capsid proteins are produced in vast excess and form hetero-oligomers, called pentons. It has been shown for Ad3 that pentons self-assemble into penton-dodecahedra (PtDd). Our previous studies with recombinant pur...
متن کاملIntercellular transfer of Ras
www.landesbioscience.com Cell Cycle 7 In recent years, it has become evident that lymphocyte are particularly adapted to form short-lived intercellular connections with the cells they scan. Such connections allow the transfer of membrane-anchored proteins, plasma membrane (PM) fragments, and even microRNAs. This “unorthodox” intercellular information transfer occurs through various incompletely...
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ژورنال
عنوان ژورنال: The Journal of Gene Medicine
سال: 1999
ISSN: 1099-498X,1521-2254
DOI: 10.1002/(sici)1521-2254(199907/08)1:4<275::aid-jgm44>3.3.co;2-d